met kinase inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6154	SU11274	Met Kinase Inhibitor,PKI-SU11274	Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
	SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.		Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
T9123	DS-1205		TAM Receptor
	DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...		TAM Receptor
T1661	Crizotinib	PF-02341066	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T3455	Merestinib	LY2801653	Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase
	Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph...
T3550	X-376	Ensartinib,X-396	c-Met/HGFR , ALK
	X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inh...		c-Met/HGFR , ALK
T8399	Crizotinib hydrochloride	PF-02341066 hydrochloride	c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
	Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)		c-Met/HGFR , ROS , ALK , Autophagy , ROS Kinase
T2054	Altiratinib	DCC-2701	VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
	Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist...		VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
T22324	Ensartinib hydrochloride	Ensartinib dihydrochloride,X-396 dihydrochloride	Others , Trk receptor , c-Met/HGFR , ALK
	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both...		Others , Trk receptor , c-Met/HGFR , ALK
T17184	Tyrosine kinase inhibitor		c-Met/HGFR , Tyrosine Kinases
	Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.		c-Met/HGFR , Tyrosine Kinases
T2516	Amuvatinib	MP470,HPK 56	Apoptosis , FLT , c-Met/HGFR , c-RET , DNA/RNA Synthesis , PDGFR , c-Kit
	Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T2586	Cabozantinib	XL184,BMS-907351	Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
	Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T21312	Afatinib	Afatinib free base,BIBW 2992	EGFR , Autophagy
	Afatinib (BIBW 2992) is an irreversible inhibitor of EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M and HER2 with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM , respectively).		EGFR , Autophagy
T5164	Cabozantinib hydrochloride	XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351	VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).		VEGFR , FLT , c-Met/HGFR , TAM Receptor , c-Kit , ROR
T1773	Afatinib Dimaleate	BIBW2992,Afatinib,BIBW 2992MA2,Afatinib (BIBW2992) Dimaleate	EGFR , HER , Autophagy
	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic act...		EGFR , HER , Autophagy
T67859	C-Met inhibitor D9		c-Met/HGFR
	C-Met inhibitor D9 is a c-Met kinase inhibitor.		c-Met/HGFR
T3209	AMG-337	AMG337	c-Met/HGFR
	AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337(AMG337) inhibits MET kinase activity (IC50: < 5 nM).		c-Met/HGFR
T8326	BMS-2		VEGFR , FLT , c-Met/HGFR
	BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.		VEGFR , FLT , c-Met/HGFR
T7900	BAY-474		c-Met/HGFR
	BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe		c-Met/HGFR
T5467	SAR125844	SAR125884	Apoptosis , c-Met/HGFR
	SAR125844, a potent and highly selective inhibitor of the MET receptor tyrosine kinase (RTK), for intravenous administration. (IC50 value of 4.2 nmol/L)		Apoptosis , c-Met/HGFR
T2676	PF-04217903		c-Met/HGFR
	MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.		c-Met/HGFR